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Acetildenafil and other synthetic structural analogs of viagra which are PDE5 inhibitors have been found as adulterants in a number of «herbal» aphrodisiac products sold over-the-counter.[25] These analogs have not undergone any of the rigorous testing that drugs like viagra have passed, and thus have unknown side-effect profiles.[26] Some attempts have been made to ban these drugs, but progress has been slow so far, as, even in those jurisdictions that have laws targeting designer drugs, the laws are drafted to ban analogs of illegal drugs of abuse, rather than analogs of prescription medicines. However, at least one court case has resulted in a product being taken off the market.[27]
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Blood pressure was measured immediately pre-dose and at 15, 30, 45 minutes, and 1, 1.5, 2, 2.5, 3, 4, 6 and 8 hours after VIAGRA or matching placebo. Outliers were defined as subjects with a standing systolic blood pressure of < 85 mmHg or a decrease from baseline in standing systolic blood pressure of > 30 mmHg at one or more timepoints. There were no subjects treated with VIAGRA 25 mg who had a standing SBP < 85mmHg. There were three subjects with a decrease from baseline in standing systolic BP > 30mmHg following VIAGRA 25 mg, one subject with a decrease from baseline in standing systolic BP > 30 mmHg following placebo and two subjects with a decrease from baseline in standing systolic BP > 30 mmHg following both VIAGRA and placebo. No severe adverse events potentially related to blood pressure effects were reported in this group.
Acetildenafil and other synthetic structural analogs of viagra which are PDE5 inhibitors have been found as adulterants in a number of «herbal» aphrodisiac products sold over-the-counter.[25] These analogs have not undergone any of the rigorous testing that drugs like viagra have passed, and thus have unknown side-effect profiles.[26] Some attempts have been made to ban these drugs, but progress has been slow so far, as, even in those jurisdictions that have laws targeting designer drugs, the laws are drafted to ban analogs of illegal drugs of abuse, rather than analogs of prescription medicines. However, at least one court case has resulted in a product being taken off the market.[27]
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